Q&A #53 with Dr. Rhonda Patrick (11/4/23)
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In this Q&A, Dr. Rhonda Patrick discusses the paradox of saturated fat in cheese, ergothioneine as a "longevity vitamin", join and sleep supplements, and red light therapy. Timestamps include:
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Do you take any specific supplements to aid sleep?
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How much olive oil do you consume daily?
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What hair care products do you use?
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How do you measure your VO2 max regularly and what is an ideal mix of zone 2 and interval training?
Is supplementing with magnesium, apigenin and L-theanine beneficial for sleep?
Magnesium
Interest in magnesium's effects on sleep is growing, and multiple mechanisms have been implicated in its role in sleep regulation.
For example, evidence suggests that magnesium is an antagonist to N-methyl-D-aspartate (NMDA) and an agonist to γ-aminobutyric acid (GABA). These compounds play critical roles in maintaining aspects of sleep architecture, particularly slow-wave sleep, which relies heavily on the glutamatergic and GABAergic systems.[1], [2], [3] Additionally, magnesium serves as an endogenous inhibitor of the NMDA receptor, promoting the cellular influx of potassium ions and enhancing sleep quality.[4] Magnesium also enhances the activity of serotonin N-acetyltransferase, an enzyme required for melatonin synthesis,[5] potentially improving sleep.[1], [2], [6] Interestingly, sleep deprivation markedly depletes magnesium levels,[7] but whether these alterations create a vicious cycle of sleep impairments is unclear.
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Q: Should we be concerned about the calcium to magnesium ratio in our diet? 1
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Q: How much olive oil do you consume daily?
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Q: Is there a preferred form of berberine? 1
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Q: Does high HDL cholesterol raise dementia risk in older adults? 1
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Q: Can garlic and grapefruit seed extract alleviate MRSA? 1
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Q: Is it better to choose triglyceride fish oil over ethyl esters to avoid atrial fibrillation risk? 1
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Q: Does dividing supplements across different meals offer any benefits? 1
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Q: Can coconut oil, estrogen, berberine, or omega-3s alter ApoB levels? 1
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Q: What hair care products do you use?
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Q: How do you measure your VO2 max regularly and what is an ideal mix of zone 2 and interval training? 1
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Q: Does DHA blunt the effects of EPA? 1
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Q: Which olive oil brand does Rhonda like?
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Watch previously recorded Q&As with Dr. Rhonda Patrick
Q&A #70 with Dr. Rhonda Patrick (5/3/25)
Dr. Rhonda Patrick discusses cancer prevention, linoleic acid, shingles vaccine and dementia, creatine's kidney effects, and shares her overnight oats recipe.
Q&A #69 with Dr. Rhonda Patrick (4/5/25)
Dr. Rhonda Patrick covers lithium microdosing, reducing homocysteine, aluminum's link to cancer, and beta-alanine and alpha-lipoic acid supplements.
Q&A #68 with Dr. Rhonda Patrick (3/1/25)
Dr. Rhonda Patrick discusses saturated fats and LDL, luteolin's benefits, glyphosate risks, natural vs. artificial flavors, and black cumin seed effects.
Q&A #67 with Dr. Rhonda Patrick (2/8/25)
Dr. Rhonda Patrick discusses microdosing nicotine, GlyNac benefits, intermittent fasting and hair loss, and cold & flu relief.
Q&A #66 with Dr. Rhonda Patrick (1/4/25)
Dr. Rhonda Patrick discusses GLP-1 agonists, alpha-lipoic acid, ubiquinone vs. ubiquinol, calcium needs, and liquid biopsy cancer screening.