Q&A #35 with Dr. Rhonda Patrick (4/30/2022)

        00:00:00 - Beginning of Q&A
00:02:42 - **Q**: Rhonda's thoughts on a recent study stating that time-restricted eating was not more beneficial than daily calorie restriction.
00:02:43 - Study: _Calorie Restriction with or without Time-Restricted Eating in Weight Loss_ [1](https://www.nejm.org/doi/full/10.1056/NEJMoa2114833)
00:08:15 - Study: _Scientists rise up against statistical significance_. [1](https://www.nature.com/articles/d41586-019-00857-9)
00:15:08 - **Q**: Will time-restricted eating make me lose lean muscle mass?
00:16:41 - Study: _Effects of time-restricted eating in adults with overweight and obesity._ [1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522780/)
00:19:38 - Study: _Men practicing time-restricted eating and resistance training maintained muscle mass._ [1](https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbTVwTlp1Si1Yc3h6Z2dmcTZ3aGEySTZ1Tkd6UXxBQ3Jtc0tsNjRBcUo3aThtMk53ckd6YmpUYXgyVnFjQ1J2dHVKSFgzNVlQTC1oaDJKa0VyaElmM2pMMmFJcTdiWTFab05GNUNGeS1Xem1pRmVYYmdkckZXb0VfZGtQVlByTlBFd2hfN1JvMnN0QmdNa1F0YVo0QQ&q=https%3A%2F%2Fdoi.org%2F10.1186%2Fs12967-016-1044-0&v=AJVOh2ensGM)
00:19:58 - **Q**: Does eating most calories early in the day have benefits over eating them later?
00:28:48 - **Q**: Is the non-nutritive sweetener allulose beneficial for health?
00:29:42 - Study: _Allulose given during a glucose challenge decreased blood glucose levels by approximately 10 percent_. [1](https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbDEza3JsVUNQMUR2UEhWa1l0SDIySndoNWsxd3xBQ3Jtc0tsWFd2aVpxY1h2bVlrbzhHbEZBYkR5WG9VQUdGWU82ckZqUjlodjd6b1BwTFM4NXJWWV9iUHF5amRiNUhkMHk3TUU3eDFSLWRhV3pWVi14dTZVS0Y2WkNWOWhhenJrU0dwai1GdTVqclZMc183UXMwOA&q=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.clnu.2020.03.002&v=AJVOh2ensGM)
00:30:09 - Study: _Allulose lowers blood glucose levels when added to meals by inhibiting enzymes in the gut that break down complex carbohydrates._ [1](https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqazY4RFVXMi1PaVNTazRQSU5VYTE5aV9Nd3owd3xBQ3Jtc0traHJLVmNocjJBWFM4R0hQX0JVZmZacnB3ZWpvaXg4cE10RmRHUGpPY2plQTMxTzlXRjl6cjlhUUlVYW5INzVqSXY1TEJnYXNUU1VCSUJvM3Z0X1VIRnZIcl9wVVgtVy0zLUZRcmR4Yy1BRWhoUDdkVQ&q=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.pharmthera.2015.08.004&v=AJVOh2ensGM)
00:33:08 - **Q**: Is there any human evidence suggesting apigenin is bioavailable and has health benefits?
00:33:50 - Review: The therapeutic potential of apigenin [1](https://doi.org/10.3390/ijms20061305)
00:36:26 - **Q**: How often should mitophagy occur — daily or pulsed?
00:37:37 - How Rhonda consumes pomegranates to obtain important polyphenols.
00:39:10 - **Q**: Should anti-inflammatory or anti-oxidant containing foods be consumed separately from exercise (either aerobic or resistance training)?
00:40:01 - Rhonda's thoughts on protein intake for longevity.
00:41:19 - Study: _High protein diet (2X RDA) preserves muscle mass in men aged over 70 years._ [1](https://doi.org/10.3945/ajcn.117.160325)
00:45:12 - **Q**: Does apigenin intake influence NAD levels?
00:46:34 - **Q**: Rhonda's thoughts on salt/sodium intake for optimal health?
00:51:55 - **Q**: Why would someone have chronically low sodium levels?
00:52:36 - **Q**: Do sulforaphane and sauna act synergistically in their detoxification efforts?
00:55:46 - **Q**: What Rhonda eats in a typical day.
01:02:32 -**Q**: Rhonda's updated thoughts on a pregnancy regimen.
01:04:38 - Recommended DHA supplement brands
01:05:35 - **Q**: Any suggestions to aid aging, sun-damaged skin?
01:06:59 - Topic Page: [Collagen](https://www.foundmyfitness.com/topics/collagen) (see skin section)
01:08:34 - **Q**: How does hydrolyzed collagen work if it is broken down by the body to amino acids?
01:10:02 - **Q**: Is it okay to take CocoaVia during pregnancy?
01:10:40 - **Q**: Can you discuss the REDUCE-IT and STRENGTH omega-3 trials?
01:11:00 - Podcast: [Dr. Bill Harris](https://www.foundmyfitness.com/episodes/bill-harris)
01:12:12- **Q**: Do you need to supplement electrolytes during time-restricted eating, exercise, and sauna?
01:14:56 - **Q**: Rhonda's thoughts on Athletic Greens.
01:17:14 - **Q**: What are the different levels of ketosis?
01:18:21 - Podcast: [Dr. Dom D'Agostino](https://www.foundmyfitness.com/episodes/dominic-dagostino-2)
01:22:01 - Topic page: [Beta-hydroxybutyrate](https://www.foundmyfitness.com/topics/beta-hydroxybutyrate)
01:22:48 - **Q**: What stem cell therapy did Tony Robbins use?
01:23:06 - **Q**: What brand and dose of sublingual zinc do you use when ill?
01:23:22 - **Q**: If someone was funding you to do a study, what hypothesis would you test?
01:23:55 - Q: How to determine the dosage of liposomal supplements?
01:25:31 - Q: Are you still taking sulforaphane?
01:26:12 - Q: Do you have a recommended skincare routine for pregnancy?
01:27:38 - Q: How does sugar intake contribute to skin aging?
01:29:18 - Q: Do you take methylated folate?
01:30:15 - Q: Should vitamin C and E be consumed separately from exercise?
01:30:48 - Topic page: [Vitamin C](https://www.foundmyfitness.com/topics/vitamin-c) (see exercise section)
01:31:20 - Q: Can you give children vitamin D and K2