Age and gender-specific effects of metformin (animal research) | Rhonda Patrick
Get the full length version of this episode as a podcast.
This episode will make a great companion for a long drive.
The Omega-3 Supplementation Guide
A blueprint for choosing the right fish oil supplement — filled with specific recommendations, guidelines for interpreting testing data, and dosage protocols.
Metformin, a drug commonly used to treat type 2 diabetes, has garnered interest as a longevity compound because it was shown to extend lifespan in some animal models. These effects are variable and seem to depend on the age and gender of the animals, as well as the dose provided. Most of the lifespan-extending benefits have been observed in female mice, with male mice being more sensitive to dosage. In this clip, Dr. Rhonda Patrick reviews the animal research that has been conducted on the potential lifespan-extending effects of metformin.
Supporting our work
If you enjoy the fruits of
, you can participate in helping us to keep improving it. Creating a premium subscription does just that! Plus, we throw in occasional member perks and, more importantly, churn out the best possible content without concerning ourselves with the wishes of any dark overlords.
Aging News
- A nearly four-decade-long study reveals that maintaining and improving a few key habits from a young age dramatically lowers the risk of cardiovascular disease after age 45.
- Regular infrared sauna use increases blood vessel density in aged muscles by 33%, though muscle size, strength, and protein synthesis remain unchanged.
- Once-weekly, low-volume resistance training boosts physical functioning, energy, and social engagement in older adults while reducing pain by up to 40% and improving strength by 30%.
- Resistance training notably improves sleep quality in older adults, outperforming both aerobic and combined exercises.
- Engaging in 30 minutes of vigorous daily exercise can offset up to five years of age-related heart health decline, but long sitting durations may undermine this benefit.
